![]() Sulfadiazine did not act as an antibacterial agent in low concentrations, but exhibited specific synergism in combination with subinhibitory levels of silver sulfadiazine. Silver, but not sulfadiazine, was bound by bacteria. The role of silver and sulfadiazine in the mechanism of action of silver sulfadiazine on burn wound infections was investigated. ![]() Mechanism of Silver Sulfadiazine Action on Burn Wound Infections We conclude that Aloe vera topical application accelerated the healing process more than thyroid hormone, silver sulfadiazine and vehicle in surgically induced incisions in rats. While the other treatment options resulted in better healing than the control group, this difference was not significant. Tensile stress was significantly improved in the Aloe vera gel group as compared with the other four groups (P≤0.05). To evaluate the efficacy of each treatment technique, a biomechanical approach was used to assess tensile stress after 14 days of treatment. In a randomized controlled trial, twelve male rats, aged 120 days and with a mean weight of 250 to 300 g, were divided randomly into 5 groups based on drug treatments: Aloe vera gel (AV), thyroid hormone cream (TC), silver sulfadiazine 1% (S), vehicle (V) and control. This study aimed at investigating the effects of topical application of an Aloe vera gel, a thyroid hormone cream and a silver sulfadiazine cream on the healing of skin wounds surgically induced in Wistar rats for determining the treatment of choice. However, the effects of these therapeutic agents are not well understood and have not been compared in one study. Many research studies report the healing effects of Aloe Vera, thyroid hormone cream and silver sulfadiazine. Norouzian, Mohsen Zarein-Dolab, Saeed Dadpay, Masoomeh Gazor, Roohollah A comparative study of the effects of topical application of Aloe vera, thyroid hormone and silver sulfadiazine on skin wounds in Wistar rats
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